7-AZAINDOLE-4-CARBOXYLIC ACID

7-AZAINDOLE-4-CARBOXYLIC ACID - Names and Identifiers

Name	1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid
Synonyms	SWF-7 7-Azaindole-4-carboxylic ... 7-Azaindole-4-carboxylic acid 7-AZAINDOLE-4-CARBOXYLIC ACID 3-b]pyridine-4-carboxylic acid 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid 1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID acide 1H-pyrrolo[2,3-b]pyridine-4-carboxylique
CAS	479553-01-0
InChI	InChI=1/C8H6N2O2/c11-8(12)6-2-4-10-7-5(6)1-3-9-7/h1-4H,(H,9,10)(H,11,12)

7-AZAINDOLE-4-CARBOXYLIC ACID - Physico-chemical Properties

Molecular Formula	C8H6N2O2
Molar Mass	162.15
Density	1.506±0.06 g/cm3(Predicted)
Melting Point	>330℃
Appearance	Solid
Color	White to cream
pKa	1.45±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.743

7-AZAINDOLE-4-CARBOXYLIC ACID - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36 - Irritating to the eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29339900
Hazard Class	IRRITANT

7-AZAINDOLE-4-CARBOXYLIC ACID - Introduction

1H-Pyrrolo [2,3-b]pyridine-4-carboxylic acid is an organic compound with the chemical formula C8H6N2O2. It is a white or yellowish solid with structural characteristics of indole and pyrrole. The following is a description of the nature, use, preparation and safety information of 1H-Pyrrolo [2,3-b]pyridine-4-carboxylic acid:

Nature:
-Appearance: White or yellowish solid
-Molecular weight: 162.15g/mol
-melting point: about 220-224 ℃
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and chloroform
-Stability: relatively stable under normal storage conditions
- pH: This compound has a neutral pH in water

Use:
-Pharmaceutical research: 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acids are often used to prepare biologically active compounds, such as drugs or biomarkers.
-Organic Synthesis: It can be used as an intermediate in organic synthesis for the construction of various organic molecules and diverse compounds.

Preparation Method:
- 1H-pyrrolo[2,3-b] The synthesis method of pyridine-4-carboxylic acid is relatively complicated, but the following is a possible preparation method:
1. First, 2-aminopyridine was synthesized by chemical reaction.
2. The 2-aminopyridine is subjected to an amidation reaction with acetone nitrile and boric acid to give 2-pyridyl propionamide.
3. 2-pyridyl propionamide reacts with phosphorus trichloride and acetic acid to generate a chloro derivative of 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid.
4. Finally, the chloro derivative reacts with hydroxylamine to form 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid.

Safety Information:
- 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid is relatively safe under proper operation, the following matters still need to be noted:
-Avoid inhalation and contact with skin or eyes, avoid ingestion.
-Wear appropriate personal protective equipment during operation, such as laboratory gloves, protective glasses and laboratory coats.
-Operate in a closed and ventilated laboratory to avoid dust.
-Observe all safe operating guidelines for the use and handling of the substance, such as waste disposal and fire protection.

Last Update：2024-04-09 21:01:54